منابع مشابه
NOD-like receptors and inflammation
The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellul...
متن کاملNOD-Like Receptors: Master Regulators of Inflammation and Cancer
Cytosolic NOD-like receptors (NLRs) have been associated with human diseases including infections, cancer, and autoimmune and inflammatory disorders. These innate immune pattern recognition molecules are essential for controlling inflammatory mechanisms through induction of cytokines, chemokines, and anti-microbial genes. Upon activation, some NLRs form multi-protein complexes called inflammaso...
متن کاملNOD-LIKE RECEPTORS (NLRs)
NLR Proteins In mammals, germ-line encoded pattern recognition receptors (PRRs) detect the presence of pathogens either directly through recognition of pathogen-associated molecular patterns (PAMPs) or indirectly through sensing host-derived danger signals (DAMPs). The innate immune system comprises several classes of PRRs that allow the early detection of pathogens at the site of infection. Th...
متن کاملToll-like receptors and NOD-like receptors in rheumatic diseases
The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spo...
متن کاملLicensing Adaptive Immunity by NOD-Like Receptors
The innate immune system is composed of a diverse set of host defense molecules, physical barriers, and specialized leukocytes and is the primary form of immune defense against environmental insults. Another crucial role of innate immunity is to shape the long-lived adaptive immune response mediated by T and B lymphocytes. The activation of pattern recognition receptors (PRRs) from the Toll-lik...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2008
ISSN: 1478-6354
DOI: 10.1186/ar2525